Inverse correlation between serum complement component C1q levels and whole blood type-1 interferon signature in active tuberculosis and QuantiFERON-positive uveitis: implications for diagnosis.

ABSTRACT:

Objectives

To examine the relation between serum C1q levels and blood type-1 interferon signature (type-1 IFN signature) in active pulmonary tuberculosis (APTB) and to determine whether combined measurement of serum C1q and type-1 IFN signature may add to the diagnosis of QuantiFERON-positive (QFT⁺) patients with uveitis of unknown cause.

Methods

C1q was determined (ELISA) in serum from two distinct Indonesian cohorts, and in total, APTB (n = 72), QFT⁺ uveitis of unknown aetiology (n = 58), QFT^- uveitis (n = 51) patients and healthy controls (HC; n = 73) were included. The type-1 IFN signature scores were previously determined.

Results

Serum C1q was higher in APTB than HC (P < 0.001). APTB patients wi

SUBMITTER: Schrijver B 

PROVIDER: S-EPMC7563643 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature