Multi-institutional Analysis of Prognostic Factors and Outcomes After Hypofractionated Stereotactic Radiotherapy to the Resection Cavity in Patients With Brain Metastases.

ABSTRACT:

Importance

For brain metastases, the combination of neurosurgical resection and postoperative hypofractionated stereotactic radiotherapy (HSRT) is an emerging therapeutic approach preferred to the prior practice of postoperative whole-brain radiotherapy. However, mature large-scale outcome data are lacking.

Objective

To evaluate outcomes and prognostic factors after HSRT to the resection cavity in patients with brain metastases.

Design, setting, and participants

An international, multi-institutional cohort study was performed in 558 patients with resected brain metastases and postoperative HSRT treated between December 1, 2003, and October 31, 2019, in 1 of 6 participating centers. Exclusion criteria were prior cranial radiotherapy (including whole-brain radiotherapy)

SUBMITTER: Eitz KA 

PROVIDER: S-EPMC7563677 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature