IgM+ and IgT+ B Cell Traffic to the Heart during SAV Infection in Atlantic Salmon.

ABSTRACT: B cells of teleost fish differentiate in the head kidney, and spleen, and either remain in the lymphatic organs or move to the blood and peripheral tissues. There is limited knowledge about piscine B cell traffic to sites of vaccination and infection and their functional roles at these sites. In this work, we examined the traffic of B cells in Atlantic salmon challenged with salmonid alphavirus (SAV). In situ hybridization (RNAScope) showed increased numbers of immunoglobin (Ig)M⁺ and IgT⁺ B cells in the heart in response to SAV challenge, with IgM⁺ B cells being most abundant. An increase in IgT⁺ B cells was also evident, indicating a role of IgT⁺ B cells in nonmucosal tissues and systemic viral infections. After infection, B cells we

SUBMITTER: Bakke AF 

PROVIDER: S-EPMC7563723 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature