Partial Similarity Reveals Dynamics in Brainstem-Midbrain Networks during Trigeminal Nociception.

ABSTRACT: Imaging studies help us understand the important role of brainstem and midbrain regions in human trigeminal pain processing without solving the question of how these regions actually interact. In the current study, we describe this connectivity and its dynamics during nociception with a novel analytical approach called Partial Similarity (PS). We developed PS specifically to estimate the communication between individual hubs of the network in contrast to the overall communication within that network. Partial Similarity works on trial-to-trial variance of neuronal activity acquired with functional magnetic resonance imaging. It discovers direct communication between two hubs considering the remainder of the network as confounds. A similar method to PS is Representational Similarity, which w

SUBMITTER: May A 

PROVIDER: S-EPMC7563756 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature