Transcriptomic Analysis of Streptococcus suis in Response to Ferrous Iron and Cobalt Toxicity.

ABSTRACT: Streptococcus suis is a zoonotic pathogen causing serious infections in swine and humans. Although metals are essential for life, excess amounts of metals are toxic to bacteria. Transcriptome-level data of the mechanisms for resistance to metal toxicity in S. suis are available for no metals other than zinc. Herein, we explored the transcriptome-level changes in S. suis in response to ferrous iron and cobalt toxicity by RNA sequencing. Many genes were differentially expressed in the presence of excess ferrous iron and cobalt. Most genes in response to cobalt toxicity showed the same expression trends as those in response to ferrous iron toxicity. qRT-PCR analysis of the selected genes confirmed the accuracy of RNA sequencing results. Bioinformatic analysis of the diffe

SUBMITTER: Jia M 

PROVIDER: S-EPMC7563783 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature