Examining the effector mechanisms of Xuebijing injection on COVID-19 based on network pharmacology.

ABSTRACT:

Background

Chinese medicine Xuebijing (XBJ) has proven to be effective in the treatment of mild coronavirus disease 2019 (COVID-19) cases. But the bioactive compounds and potential mechanisms of XBJ for COVID-19 prevention and treatment are unclear. This study aimed to examine the potential effector mechanisms of XBJ on COVID-19 based on network pharmacology.

Methods

We searched Chinese and international papers to obtain the active ingredients of XBJ. Then, we compiled COVID-19 disease targets from the GeneCards gene database and via literature searches. Next, we used the SwissTargetPrediction database to predict XBJ's effector targets and map them to the abovementioned COVID-19 disease targets in order to obtain potential therapeutic targets of XBJ. Cytoscape software versi

SUBMITTER: Zheng WJ 

PROVIDER: S-EPMC7563914 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature