Characterization of Inactivated Influenza Vaccines Used in the Russian National Immunization Program.

ABSTRACT: today's standard quality control methods used to control the protein composition of inactivated influenza vaccines only take into account a few key reference components. They do not allow for thorough characterization of protein compositions. As a result, observation of unpredictable variations in major viral constituents and admixtures of cellular proteins within manufactured vaccines that may seriously influence the immunogenicity and safety of such vaccines has become a pressing issue in vaccinology. This study aims at testing a more sophisticated approach for analysis of inactivated split influenza vaccines licensed in the Russian Federation. The formulations under study are the most available on the market and are included in the Russian National Immunization Program. liquid chromatog

SUBMITTER: Tarasov M 

PROVIDER: S-EPMC7564049 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature