Low ARID1A Expression is Associated with Poor Prognosis in Hepatocellular Carcinoma.

ABSTRACT: AT-rich interactive domain 1A (ARID1A) is one of the most frequently mutated genes in hepatocellular carcinoma (HCC), but its clinical significance is not clarified. We aimed to evaluate the clinical significance of low ARID1A expression in HCC. By analyzing the gene expression data of liver from Arid1a-knockout mice, hepatic Arid1a-specific gene expression signature was identified (p < 0.05 and 0.5-fold difference). From this signature, a prediction model was developed to identify tissues lacking Arid1a activity and was applied to gene expression data from three independent cohorts of HCC patients to stratify patients according to ARID1A activity. The molecular features associated with loss of ARID1A were analyzed using The Cancer Ge

SUBMITTER: Yim SY 

PROVIDER: S-EPMC7564185 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature