Variants of genes encoding TNF receptors and ligands and proteins regulating TNF activation in familial multiple sclerosis.

ABSTRACT:

Introduction

Numerous genetic variants have been associated with susceptibility to multiple sclerosis (MS). Variants located in genes involved in specific pathways, such as those affecting TNF-α, can contribute to the risk of MS. The purpose of this study was to determine whether variants of these genes are associated with greater risk of MS.

Methods

We used whole-exome sequencing to study genes coding for TNF-α receptors and ligands, and proteins promoting TNF-α expression in 116 individuals from 19 families including at least two MS patients. We compared patients with MS, patients with other autoimmune diseases, and healthy individuals.

Results

Greater polymorphism was observed in several genes in families with familial MS compared to the general population; this ma

SUBMITTER: Torre-Fuentes L 

PROVIDER: S-EPMC7564193 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature