Atg8-Family Proteins-Structural Features and Molecular Interactions in Autophagy and Beyond.

ABSTRACT: Autophagy is a common name for a number of catabolic processes, which keep the cellular homeostasis by removing damaged and dysfunctional intracellular components. Impairment or misbalance of autophagy can lead to various diseases, such as neurodegeneration, infection diseases, and cancer. A central axis of autophagy is formed along the interactions of autophagy modifiers (Atg8-family proteins) with a variety of their cellular counter partners. Besides autophagy, Atg8-proteins participate in many other pathways, among which membrane trafficking and neuronal signaling are the most known. Despite the fact that autophagy modifiers are well-studied, as the small globular proteins show similarity to ubiquitin on a structural level, the mechanism of their interactions are still not completely un

SUBMITTER: Wesch N 

PROVIDER: S-EPMC7564214 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature