Aneuploidy and DNA Methylation as Mirrored Features of Early Human Embryo Development.

ABSTRACT: Genome stability is an integral feature of all living organisms. Aneuploidy is the most common cause of fetal death in humans. The timing of bursts in increased aneuploidy frequency coincides with the waves of global epigenetic reprogramming in mammals. During gametogenesis and early embryogenesis, parental genomes undergo two waves of DNA methylation reprogramming. Failure of these processes can critically affect genome stability, including chromosome segregation during cell division. Abnormal methylation due to errors in the reprogramming process can potentially lead to aneuploidy. On the other hand, the presence of an entire additional chromosome, or chromosome loss, can affect the global genome methylation level. The associations of these two phenomena are well studied in the context o

SUBMITTER: Tolmacheva EN 

PROVIDER: S-EPMC7564410 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature