The Impact of Obesity on the Severity of Clinicopathologic Parameters in Patients with IgA Nephropathy.

ABSTRACT: Several studies reported the effect of obesity on the progression of IgA nephropathy (IgAN). However, the impact of obesity on the clinicopathologic presentation of IgAN remains uncertain. This is a retrospective cross-sectional study from eight university hospitals in South Korea. Patients were categorized into three groups using the Asia-Pacific obesity classification based on body mass index (BMI). Clinical and histopathologic data at the time of renal biopsy were analyzed. Among 537 patients with IgAN, the obese group was more hypertensive and had lower estimated glomerular filtration rate and more proteinuria than other groups. The histologic scores for mesangial matrix expansion (MME), interstitial fibrosis, tubular atrophy, and mesangial C3 deposition differed significantly between

SUBMITTER: Hong YA 

PROVIDER: S-EPMC7564413 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature