Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity.

ABSTRACT: Background: Several studies have shown that healthy lifestyles prevent the risk of breast cancer (BC) and are associated with better prognosis. It was hypothesized that lifestyle strategies induce microRNA (miRNA) modulation that, in turn, may lead to important epigenetic modifications. The identification of miRNAs associated with BC, diet, and physical activity may give further insights into the role played by lifestyle interventions and their efficacy for BC patients. To predict which miRNAs may be modulated by diet and physical activity in BC patients, the analyses of different miRNA expression datasets were performed. Methods: The GEO DataSets database was used to select miRNA expression datasets related to BC patients, dietary interventions, and physical exercise. Further bioinformati

SUBMITTER: Falzone L 

PROVIDER: S-EPMC7564431 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature