DNA FISH Diagnostic Assay on Cytological Samples of Thyroid Follicular Neoplasms.

ABSTRACT: Although fine-needle aspiration cytology (FNAC) is helpful in determining whether thyroid nodules are benign or malignant, this distinction remains a cytological challenge in follicular neoplasms. Identification of genomic alterations in cytological specimens with direct and routine techniques would therefore have great clinical value. A series of 153 cases consisting of 72 and 81 histopathologically confirmed classic follicular adenomas (cFAs) and classic follicular thyroid carcinomas (cFTCs), respectively, was studied by means of different molecular techniques in three different cohorts of patients (pts). In the first cohort (training set) of 66 pts, three specific alterations characterized by array comparative genomic hybridization (aCGH) were exclusively found in half of cFTCs. These s

SUBMITTER: Vielh P 

PROVIDER: S-EPMC7564487 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature