Hepatitis E Virus Mediates Renal Injury via the Interaction between the Immune Cells and Renal Epithelium.

ABSTRACT: Renal disorders are associated with Hepatitis E virus (HEV) infection. Progression to end-stage renal disease and acute kidney injury are complications associated with HEV infection. The mechanisms by which HEV mediates the glomerular diseases remain unclear. CD10⁺/CD13⁺ primary proximal tubular (PT) epithelial cells, isolated from healthy donors, were infected with HEV. Inflammatory markers and kidney injury markers were assessed in the presence or absence of peripheral blood mononuclear cells (PBMCs) isolated from the same donors. HEV replicated efficiently in the PT cells as shown by the increase in HEV load over time and the expression of capsid Ag. In the absence of PBMCs, HEV was not nephrotoxic, with no direct effect on the transcription of chemokines (Cxcl-9,

SUBMITTER: El-Mokhtar MA 

PROVIDER: S-EPMC7564770 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature