Plasma C-Peptide and Risk of Developing Type 2 Diabetes in the General Population.

ABSTRACT: C-peptide measurement may represent a better index of pancreatic β-cell function compared to insulin. While insulin is mainly cleared by liver, C-peptide is mainly metabolized by kidneys. The aim of our study was to evaluate the association between baseline plasma C-peptide level and the development of type 2 diabetes independent of glucose and insulin levels and to examine potential effect-modification by variables related to kidney function. We included 5176 subjects of the Prevention of Renal and Vascular End-Stage Disease study without type 2 diabetes at baseline. C-peptide was measured in plasma with an electrochemiluminescent immunoassay. Cox proportional hazards regression was used to evaluate the association between C-peptide level and type 2 diabetes development. Median C-peptide

SUBMITTER: Sokooti S 

PROVIDER: S-EPMC7564789 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature