Is Host Metabolism the Missing Link to Improving Cancer Outcomes?

ABSTRACT: For the past 100 years, oncologists have relentlessly pursued the destruction of tumor cells by surgical, chemotherapeutic or radiation oncological means. Consistent with this focus, treatment plans are typically based on key characteristics of the tumor itself such as disease site, histology and staging based on local, regional and systemic dissemination. Precision medicine is similarly built on the premise that detailed knowledge of molecular alterations of tumor cells themselves enables better and more effective tumor cell destruction. Recently, host factors within the tumor microenvironment including the vasculature and immune systems have been recognized as modifiers of disease progression and are being targeted for therapeutic gain. In this review, we argue that-to optimize the impac

SUBMITTER: Wright CM 

PROVIDER: S-EPMC7564800 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature