3D Printing of a Reactive Hydrogel Bio-Ink Using a Static Mixing Tool.

ABSTRACT: Hydrogel-based bio-inks have recently attracted more attention for 3D printing applications in tissue engineering due to their remarkable intrinsic properties, such as a cell supporting environment. However, their usually weak mechanical properties lead to poor printability and low stability of the obtained structures. To obtain good shape fidelity, current approaches based on extrusion printing use high viscosity solutions, which can compromise cell viability. This paper presents a novel bio-printing methodology based on a dual-syringe system with a static mixing tool that allows in situ crosslinking of a two-component hydrogel-based ink in the presence of living cells. The reactive hydrogel system consists of carboxymethyl chitosan (CMCh) and partially oxidized hyaluronic acid (HAox) tha

SUBMITTER: Puertas-Bartolome M 

PROVIDER: S-EPMC7564821 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature