Prediction of Severe Lymphopenia During Chemoradiation Therapy for Esophageal Cancer: Development and Validation of a Pretreatment Nomogram.

ABSTRACT:

Introduction

In patients with esophageal cancer, occurrence of severe radiation-induced lymphopenia during chemoradiation therapy has been associated with worse progression-free and overall survival. The aim of this study was to develop and validate a pretreatment clinical nomogram for the prediction of grade 4 lymphopenia.

Methods and materials

A development set of consecutive patients who underwent chemoradiation therapy for esophageal cancer and an independent validation set of patients from another institution were identified. Grade 4 lymphopenia was defined as an absolute lymphocyte count nadir during chemoradiation therapy of <0.2 × 10³/μL. Multivariable logistic regression analysis was used to create a prediction model for grade 4 lymphopenia in the develop

SUBMITTER: van Rossum PSN 

PROVIDER: S-EPMC7564893 | biostudies-literature | 2020 Jan - Feb

REPOSITORIES: biostudies-literature