A Toll-Spatzle Pathway in the Immune Response of Bombyx mori.

ABSTRACT: The Toll-Spätzle pathway is a crucial defense mechanism in insect innate immunity, it plays an important role in fighting against pathogens through the regulation of antimicrobial peptide gene expression. Although Toll and Spätzle (Spz) genes have been identified in Bombyx mori, little is known regarding the specific Spz and Toll genes members involved in innate immunity. There is also limited direct evidence of the interaction between Spz and Toll. In this study, the dual-luciferase reporter assay results showed that BmToll11 and BmToll9-1 could activate both drosomycin and diptericin promoters in S2 cells. Furthermore, BmToll11, BmToll9-1, and five BmSpzs genes were found to be significantly upregulated in B. mori infected by Escherichia coli and Staphylococcus aureus. Additionally, the

SUBMITTER: Yu B 

PROVIDER: S-EPMC7564906 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature