Immunohistochemical Characterization of Immune Infiltrate in Tumor Microenvironment of Glioblastoma.

ABSTRACT: Glioblastoma (GBM) is the most common primary malignant brain cancer in adults, with very limited therapeutic options. It is characterized by a severe immunosuppressive milieu mostly triggered by suppressive CD163+ tumor-associated macrophages (TAMs). The efficacy of immune checkpoint inhibitor interventions aimed at rescuing anti-tumor immunity has not been proved to date. Thus, it is critically important to investigate the immunomodulatory mechanisms acting within the GBM microenvironment for the better design of immunotherapeutic strategies. The immunohistochemical analysis of a panel of immune biomarkers (CD3, FoxP3, CD163, IDO, PDL-1, PD-1 and TIGIT) was performed in paired samples of the tumor core (TC) and peritumoral area (PTA) of nine GBM patients. CD163+ cells were the most commo

SUBMITTER: Rahimi Koshkaki H 

PROVIDER: S-EPMC7564919 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature