N-Terminal Acetyltransferases Are Cancer-Essential Genes Prevalently Upregulated in Tumours.

ABSTRACT: N-terminal acetylation (Nt-Ac) is an abundant eukaryotic protein modification, deposited in humans by one of seven N-terminal acetyltransferase (NAT) complexes composed of a catalytic and potentially auxiliary subunits. The involvement of NATs in cancers is being increasingly recognised, but a systematic cross-tumour assessment is currently lacking. To address this limitation, we conducted here a multi-omic data interrogation for NATs. We found that tumour genomic alterations of NATs or of their protein substrates are generally rare events, with some tumour-specific exceptions. In contrast, altered gene expression of NATs in cancers and their association with patient survival constitute a widespread cancer phenomenon. Examination of dependency screens revealed that (i), besides NAA60 and N

SUBMITTER: Koufaris C 

PROVIDER: S-EPMC7565035 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature