The Involvement of Hypothalamus-Pituitary-Adrenal (HPA) Axis in Suicide Risk.

ABSTRACT: Stress and Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation play a major role in various pathophysiological processes associated with both mood disorders and suicidal behavior. We conducted a systematic review with the primary aim of clarifying the nature and extent of HPA axis activity and suicidal behavior. The second aim of this review was to investigate whether potential biomarkers related to HPA axis abnormalities act as individual susceptibility factors for suicide. The PRISMA statement for reporting systematic reviews was used. Only articles published in English peer-reviewed journals were considered for possible inclusion; we excluded case reports, meta-analyses, and systematic reviews, and studies that did not clearly report statistical analysis, diagnostic criteria, or the

SUBMITTER: Berardelli I 

PROVIDER: S-EPMC7565104 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature