Potent Protective Immune Responses to Senecavirus Induced by Virus-Like Particle Vaccine in Pigs.

ABSTRACT: Senecavirus A (SVA) is the pathogen that has recently caused porcine idiopathic vesicular disease (PIVD). The clinical symptoms of PIVD are similar to those of acute foot-and-mouth disease and also can result in the death of newborn piglets, thus entailing economic losses. Vaccine immunization is the most effective way to prevent and control SVA. Among all SVA vaccines reported, only the SVA inactivated vaccine has been successfully developed. However, to ensure the elimination of this pathogen, safer and more effective vaccines are urgently required. A virus-like particles (VLPs)-based vaccine is probably the best alternative to inactivated vaccine. To develop an SVA VLPs vaccine and evaluate its immune effect, a prokaryotic expression system was used to produce SVA capsid protein and ass

SUBMITTER: Mu S 

PROVIDER: S-EPMC7565160 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature