RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination.

ABSTRACT: RAS mutations are the second most common genetic alteration in thyroid tumors. However, the extent to which they are associated with the most aggressive phenotypes is still controversial. Regarding their malignancy, the majority of RAS mutant tumors are classified as undetermined, which complicates their clinical management and can lead to undesired under- or overtreatment. Using the chick embryo spontaneous metastasis model, we herein demonstrate that the aggressiveness of HRAS-transformed thyroid cells, as determined by the ability to extravasate and metastasize at distant organs, is orchestrated by HRAS subcellular localization. Remarkably, aggressiveness inversely correlates with tumor size. In this respect, we also show that RAS site-specific capacity to regulate tumor g

SUBMITTER: Garcia-Ibanez Y 

PROVIDER: S-EPMC7565207 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature