Patients with myeloproliferative neoplasms and high levels of systemic inflammation develop age-related macular degeneration.

ABSTRACT:

Background

Epidemiological data show that myeloproliferative neoplasms (MPNs) are associated with increased risk of neovascular age-related macular degeneration (AMD). However, knowledge about the retinal findings in these patients is lacking. This study was conducted to examine retinal ageing and the prevalence of a hallmark of AMD; drusen, in patients with MPNs. Further, we examine the role of chronic systemic inflammation, considered central in both AMD and MPNs.

Methods

In this single-centre cross-sectional study, we consecutively enrolled 200 patients with MPNs. The study was divided into three substudies. Firstly, we obtained colour fundus photographs from all patients to evaluate and compare the prevalence of drusen with the published estimates from three large popula

SUBMITTER: Liisborg C 

PROVIDER: S-EPMC7565257 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature