Influenza A Virus Vaccination: Immunity, Protection, and Recent Advances Toward A Universal Vaccine.

ABSTRACT: Influenza virus infections represent a serious public health threat and account for significant morbidity and mortality worldwide due to seasonal epidemics and periodic pandemics. Despite being an important countermeasure to combat influenza virus and being highly efficacious when matched to circulating influenza viruses, current preventative strategies of vaccination against influenza virus often provide incomplete protection due the continuous antigenic drift/shift of circulating strains of influenza virus. Prevention and control of influenza virus infection with vaccines is dependent on the host immune response induced by vaccination and the various vaccine platforms induce different components of the local and systemic immune response. This review focuses on the immune basis of current

SUBMITTER: Lopez CE 

PROVIDER: S-EPMC7565301 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature