Targeting the Id1-Kif11 Axis in Triple-Negative Breast Cancer Using Combination Therapy.

ABSTRACT: The basic helix-loop-helix (bHLH) transcription factors inhibitor of differentiation 1 (Id1) and inhibitor of differentiation 3 (Id3) (referred to as Id) have an important role in maintaining the cancer stem cell (CSC) phenotype in the triple-negative breast cancer (TNBC) subtype. In this study, we aimed to understand the molecular mechanism underlying Id control of CSC phenotype and exploit it for therapeutic purposes. We used two different TNBC tumor models marked by either Id depletion or Id1 expression in order to identify Id targets using a combinatorial analysis of RNA sequencing and microarray data. Phenotypically, Id protein depletion leads to cell cycle arrest in the G0/G1 phase, which we demonstrate is reversible. In order to under

SUBMITTER: Thankamony AP 

PROVIDER: S-EPMC7565337 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature