Breast and Gut Microbiota Action Mechanisms in Breast Cancer Pathogenesis and Treatment.

ABSTRACT: In breast cancer (BC) the employment of sequencing technologies for metagenomic analyses has allowed not only the description of the overall metagenomic landscape but also the specific microbial changes and their functional implications. Most of the available data suggest that BC is related to bacterial dysbiosis in both the gut microenvironment and breast tissue. It is hypothesized that changes in the composition and functions of several breast and gut bacterial taxa may contribute to BC development and progression through several pathways. One of the most prominent roles of gut microbiota is the regulation of steroid-hormone metabolism, such as estrogens, a component playing an important role as risk factor in BC development, especially in postmenopausal women. On the other hand, breast

SUBMITTER: Laborda-Illanes A 

PROVIDER: S-EPMC7565530 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature