Epigenetic Programming Through Breast Milk and Its Impact on Milk-Siblings Mating.

ABSTRACT:

Background

The epigenetic effects of transmission of certain regulatory molecules, such as miRNAs, through maternal milk on future generations, are still unknown and have not been fully understood yet. We hypothesized that breastfeeding regularly by adoptive-mother may cause transmission of miRNAs as epigenetic regulating factors to the infant, and the marriage of milk-siblings may cause various pathologies in the future generations.

Results

A cross-fostering model using a/a and A ^vy /a mice had been established. F2 milk-sibling and F2 control groups were obtained from mating of milk-siblings or unrelated mice. Randomized selected animals in the both F2 groups were sacrificed for miRNA expression studies and the remainings were followed for phenotypi

SUBMITTER: Ozkan H 

PROVIDER: S-EPMC7565666 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature