Corpus Callosum Agenesis: An Insight into the Etiology and Spectrum of Symptoms.

ABSTRACT: Brain hemispheres are connected by commissural structures, which consist of white matter fiber tracts that spread excitatory stimuli to various regions of the cortex. This allows an interaction between the two cerebral halves. The largest commissure is the corpus callosum (CC) which is located inferior to the longitudinal fissure, serving as its lower border. Sometimes this structure is not completely developed, which results in the condition known as agenesis of the corpus callosum (ACC). The aim of this paper was to review the latest discoveries related to the genetic and metabolic background of ACC, including the genotype/phenotype correlations as well as the clinical and imaging symptomatology. Due to various factors, including genetic defects and metabolic diseases, the development of

SUBMITTER: Hofman J 

PROVIDER: S-EPMC7565833 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature