High-Resolution Genome-Wide Occupancy in Candida spp. Using ChEC-seq.

ABSTRACT: To persist in their dynamic human host environments, fungal pathogens must sense and adapt by modulating their gene expression to fulfill their cellular needs. Understanding transcriptional regulation on a global scale would uncover cellular processes linked to persistence and virulence mechanisms that could be targeted for antifungal therapeutics. Infections associated with the yeast Candida albicans, a highly prevalent fungal pathogen, and the multiresistant related species Candida auris are becoming a serious public health threat. To define the set of a gene regulated by a transcriptional regulator in C. albicans, chromatin immunoprecipitation (ChIP)-based techniques, including ChIP with microarray technology (ChIP-chip) or ChIP-DNA sequencing (ChIP-seq), have been

SUBMITTER: Tebbji F 

PROVIDER: S-EPMC7565893 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature