Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells.

ABSTRACT: Despite the leaps and bounds in achieving success in the management and treatment of breast cancers through surgery, chemotherapy, and radiotherapy, breast cancer remains the most frequently occurring cancer in women and the most common cause of cancer-related deaths among women. Systemic therapeutic approaches, such as chemotherapy, although beneficial in treating and curing breast cancer subjects with localized breast tumors, tend to fail in metastatic cases of the disease due to (a) an acquired resistance to the chemotherapeutic drug and (b) the development of intrinsic resistance to therapy. The existence of cancer stem cells (CSCs) plays a crucial role in both acquired and intrinsic chemoresistance. CSCs are less abundant than terminally differentiated cancer cells and confer chemores

SUBMITTER: Samuel SM 

PROVIDER: S-EPMC7565921 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature