Genome-Wide Comparison of the Target Genes of the Reactive Oxygen Species and Non-Reactive Oxygen Species Constituents of Cold Atmospheric Plasma in Cancer Cells.

ABSTRACT: Cold atmospheric plasma (CAP) can induce cancer cell death. The majority of gene regulation studies have been biased towards reactive oxygen species (ROS) among the physicochemical components of CAP. The current study aimed to systemically determine the distribution of target genes regulated by the ROS and non-ROS constituents of CAP. Genome-wide expression data from a public database, which were obtained after treating U937 leukemia and SK-mel-147 melanoma cells with CAP or H₂O₂, were analyzed, and gene sets regulated by either or both of them were identified. The results showed 252 and 762 genes in H₂O₂-treated U937 and SK-mel-147 cells, respectively, and 112 and 843 genes in CAP-treated U937 and SK-mel-147 cells, respectively, with expression

SUBMITTER: Ji HW 

PROVIDER: S-EPMC7565996 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature