Human germinal centres engage memory and naive B cells after influenza vaccination.

ABSTRACT: Influenza viruses remain a major public health threat. Seasonal influenza vaccination in humans primarily stimulates pre-existing memory B cells, which differentiate into a transient wave of circulating antibody-secreting plasmablasts^1-3. This recall response contributes to 'original antigenic sin'-the selective increase of antibody species elicited by previous exposures to influenza virus antigens⁴. It remains unclear whether such vaccination can also induce germinal centre reactions in the draining lymph nodes, where diversification and maturation of recruited B cells can occur⁵. Here we used ultrasound-guided fine needle aspiration to serially sample the draining lymph nodes and investigate the dynamics and specificity of germinal centre B cell responses

SUBMITTER: Turner JS 

PROVIDER: S-EPMC7566073 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature