Progress and Pitfalls in the Quest for Effective SARS-CoV-2 (COVID-19) Vaccines.

ABSTRACT: There are currently around 200 SARS-CoV-2 candidate vaccines in preclinical and clinical trials throughout the world. The various candidates employ a range of vaccine strategies including some novel approaches. Currently, the goal is to prove that they are safe and immunogenic in humans (phase 1/2 studies) with several now advancing into phase 2 and 3 trials to demonstrate efficacy and gather comprehensive data on safety. It is highly likely that many vaccines will be shown to stimulate antibody and T cell responses in healthy individuals and have an acceptable safety profile, but the key will be to confirm that they protect against COVID-19. There is much hope that SARS-CoV-2 vaccines will be rolled out to the entire world to contain the pandemic and avert its most damaging impacts. Howev

SUBMITTER: Flanagan KL 

PROVIDER: S-EPMC7566192 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature