Triclosan disrupts immune cell function by depressing Ca²⁺ influx following acidification of the cytoplasm.

ABSTRACT: Triclosan (TCS) is an antimicrobial agent that was effectively banned by the FDA from hand soaps in 2016, hospital soaps in 2017, and hand sanitizers in 2019; however, TCS can still be found in a few products. At consumer-relevant, non-cytotoxic doses, TCS inhibits the functions of both mitochondria and mast cells, a ubiquitous cell type. Via the store-operated Ca²⁺ entry mechanism utilized by many immune cells, mast cells undergo antigen-stimulated Ca²⁺ influx into the cytosol, for proper function. Previous work showed that TCS inhibits Ca²⁺ dynamics in mast cells, and here we show that TCS also inhibits Ca²⁺ mobilization in human Jurkat T cells. However, the biochemical mechanism behind the Ca²⁺ dampening has yet to be elucidated. Th

SUBMITTER: Sangroula S 

PROVIDER: S-EPMC7566221 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature