¹H, ¹³C, ¹⁵ N chemical shift assignments of the FKBP12 protein from the pathogenic fungi Candida auris and Candida glabrata.

ABSTRACT: Multi-drug resistance is becoming an increasingly severe clinical challenge not only among pathogenic bacteria but among fungal pathogens as well. Drug design is inherently more challenging for the eukaryotic fungi due to their closer evolutionary similarity to humans. The recent rapid expansion in invasive infections throughout the world by Candida auris is of particular concern due to a substantial mortality rate, comparatively facile transmission, and an increasing level of resistance to all three of the major classes of anti-fungal drugs. One promising avenue for the development of an alternative class of anti-fungal agents currently under investigation is for drugs against the FK506-binding protein FKBP12 which, when bound to that drug, inhibits the fungal calcineurin signaling pathwa

SUBMITTER: Bashir Q 

PROVIDER: S-EPMC7566231 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature