Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms.

ABSTRACT:

Background and aim

Feline immunodeficiency virus (FIV) causes AIDS-like symptoms in domestic and wild cats. Treatment of infected cats has been performed using human anti-HIV drugs, which showed some limitations. This study aimed to determine the anti-FIV potential of some mushrooms.

Materials and methods

A total of 17 medicinal and edible mushrooms were screened to find their inhibitory effect against FIV reverse transcriptase (FIV-RT). Three solvents, water, ethanol, and hexane, were used to prepare crude mushroom extracts. Fluorescence spectroscopy was used to perform relative inhibition and 50% inhibitory concentrations (IC₅₀) studies.

Results

The ethanol extract from dried fruiting bodies of Inonotus obliquus showed the strongest inhibition with

SUBMITTER: Seetaha S 

PROVIDER: S-EPMC7566271 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature