Nucleus-specific modulation of phasic and tonic inhibition by endogenous neurosteroidogenesis in the murine thalamus.

ABSTRACT: Neurosteroids are potent allosteric modulators of GABA_A receptors (GABA_A Rs). Although the effects of exogenous neurosteroids on GABA_A R function are well documented, less is known about effects of neurosteroids produced by local endogenous biosynthesis. The neurosteroidogenic enzymes 5α-reductase and 3α-hydroxysteroid dehydrogenase are expressed in two nuclei of somatosensory thalamus, the thalamic reticular nucleus (nRT) and ventrobasal nucleus (VB). Here, the effects of acute blockade of neurosteroidogenesis by the 5α-reductase inhibitor finasteride on phasic and tonic GABA_A R-mediated currents were examined in nRT and VB of mice. In nRT, finasteride altered the decay and amplitude, but not the frequency, of phasic currents, with no effect on

SUBMITTER: Christian CA 

PROVIDER: S-EPMC7566274 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature