Clofazimine pharmacokinetics in patients with TB: dosing implications.

ABSTRACT:

Background

Clofazimine is in widespread use as a key component of drug-resistant TB regimens, but the recommended dose is not evidence based. Pharmacokinetic data from relevant patient populations are needed to inform dose optimization.

Objectives

To determine clofazimine exposure, evaluate covariate effects on variability, and simulate exposures for different dosing strategies in South African TB patients.

Patients and methods

Clinical and pharmacokinetic data were obtained from participants with pulmonary TB enrolled in two studies with intensive and sparse sampling for up to 6 months. Plasma concentrations were measured by LC-MS/MS and interpreted with non-linear mixed-effects modelling. Body size descriptors and other potential covariates were tested on pharmacoki

SUBMITTER: Abdelwahab MT 

PROVIDER: S-EPMC7566350 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature