Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis.

ABSTRACT:

Background

The rise of antimicrobial drug resistance in Mycobacterium tuberculosis coupled with the shortage of new antibiotics has elevated TB to a major global health priority. Repurposing drugs developed or used for other conditions has gained special attention in the current scenario of accelerated drug development for several global infectious diseases. In a similar effort, previous studies revealed that carprofen, a non-steroidal anti-inflammatory drug, selectively inhibited the growth of replicating, non-replicating and MDR clinical isolates of M. tuberculosis.

Objectives

We aimed to reveal the whole-cell phenotypic and transcriptomic effects of carprofen in mycobacteria.

Methods

Integrative molecular and microbiological approaches such as resazurin microtitre

SUBMITTER: Maitra A 

PROVIDER: S-EPMC7566368 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature