Clinical impact of combined epigenetic and molecular analysis of pediatric low-grade gliomas.

ABSTRACT:

Background

Both genetic and methylation analysis have been shown to provide insight into the diagnosis and prognosis of many brain tumors. However, the implication of methylation profiling and its interaction with genetic alterations in pediatric low-grade gliomas (PLGGs) are unclear.

Methods

We performed a comprehensive analysis of PLGG with long-term clinical follow-up. In total 152 PLGGs were analyzed from a range of pathological subtypes, including 40 gangliogliomas. Complete molecular analysis was compared with genome-wide methylation data and outcome in all patients. For further analysis of specific PLGG groups, including BRAF p.V600E mutant gliomas, we compiled an additional cohort of clinically and genetically defined tumors from 3 large centers.

Results

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SUBMITTER: Fukuoka K 

PROVIDER: S-EPMC7566385 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature