An Understandable, Extensible, and Reusable Implementation of the Hodgkin-Huxley Equations Using Modelica.

ABSTRACT: The Hodgkin-Huxley model of the squid giant axon has been used for decades as the basis of many action potential models. These models are usually communicated using just a list of equations or a circuit diagram, which makes them unnecessarily complicated both for novices and for experts. We present a modular version of the Hodgkin-Huxley model that is more understandable than the usual monolithic implementations and that can be easily reused and extended. Our model is written in Modelica using software engineering concepts, such as object orientation and inheritance. It retains the electrical analogy, but names and explains individual components in biological terms. We use cognitive load theory to measure understandability as the amount of items that have to be kept in working memory simul

SUBMITTER: Scholzel C 

PROVIDER: S-EPMC7566415 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature