Evaluation of Durability of a Single Dose of the Bivalent HPV Vaccine: The CVT Trial.

ABSTRACT:

Background

The authors investigated the durability of vaccine efficacy (VE) against human papillomavirus (HPV)16 or 18 infections and antibody response among nonrandomly assigned women who received a single dose of the bivalent HPV vaccine compared with women who received multiple doses and unvaccinated women.

Methods

HPV infections were compared between HPV16 or 18-vaccinated women aged 18 to 25 years who received one (N = 112), two (N = 62), or three (N = 1365) doses, and age- and geography-matched unvaccinated women (N = 1783) in the long-term follow-up of the Costa Rica HPV Vaccine Trial. Cervical HPV infections were measured at two study visits, approximately 9 and 11 years after initial HPV vaccination, using National Cancer Institute next-generation sequencing TypeSeq

SUBMITTER: Kreimer AR 

PROVIDER: S-EPMC7566548 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature