Investigating the NPY/AgRP/GABA to GnRH Neuron Circuit in Prenatally Androgenized PCOS-Like Mice.

ABSTRACT: Polycystic ovary syndrome (PCOS), the most common form of anovulatory infertility, is associated with altered signaling within the hormone-sensitive neuronal network that regulates gonadotropin-releasing hormone (GnRH) neurons, leading to a pathological increase in GnRH secretion. Circuit remodeling is evident between GABAergic neurons in the arcuate nucleus (ARN) and GnRH neurons in a murine model of PCOS. One-third of ARN GABA neurons co-express neuropeptide Y (NPY), which has a known yet complex role in regulating GnRH neurons and reproductive function. Here, we investigated whether the NPY-expressing subpopulation (NPY^ARN) of ARN GABA neurons (GABA^ARN) is also affected in prenatally androgenized (PNA) PCOS-like NPY^ARN reporter mice [Agouti-related prote

SUBMITTER: Marshall CJ 

PROVIDER: S-EPMC7566551 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature