Cyclase-associated protein 2 dimerization regulates cofilin in synaptic plasticity and Alzheimer's disease.

ABSTRACT: Regulation of actin cytoskeleton dynamics in dendritic spines is crucial for learning and memory formation. Hence, defects in the actin cytoskeleton pathways are a biological trait of several brain diseases, including Alzheimer's disease. Here, we describe a novel synaptic mechanism governed by the cyclase-associated protein 2, which is required for structural plasticity phenomena and completely disrupted in Alzheimer's disease. We report that the formation of cyclase-associated protein 2 dimers through its Cys³² is important for cyclase-associated protein 2 binding to cofilin and for actin turnover. The Cys³²-dependent cyclase-associated protein 2 homodimerization and association to cofilin are triggered by long-term potentiation and are required for long-term potent

SUBMITTER: Pelucchi S 

PROVIDER: S-EPMC7566557 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature