Surveillance of HIV-1 transmitted integrase strand transfer inhibitor resistance in the UK.

ABSTRACT:

Background

HIV treatment guidelines have traditionally recommended that all HIV-positive individuals are tested for evidence of drug resistance prior to starting ART. Testing for resistance to reverse transcriptase inhibitors and PIs is well established in routine care. However, testing for integrase strand transfer inhibitor (InSTI) resistance is less consistent.

Objectives

To inform treatment guidelines by determining the prevalence of InSTI resistance in a national cohort of recently infected individuals.

Patients and methods

Recent (within 4 months) HIV-1 infections were identified using a Recent Infection Testing Algorithm of new HIV-1 diagnoses in the UK. Resistance-associated mutations (RAMs) in integrase, protease and reverse transcriptase were detected by ult

SUBMITTER: Mbisa JL 

PROVIDER: S-EPMC7566560 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature