Sex Differences in Variability of Brain Structure Across the Lifespan.

ABSTRACT: Several brain disorders exhibit sex differences in onset, presentation, and prevalence. Increased understanding of the neurobiology of sex-based differences in variability across the lifespan can provide insight into both disease vulnerability and resilience. In n = 3069 participants, from 8 to 95 years of age, we found widespread greater variability in males compared with females in cortical surface area and global and subcortical volumes for discrete brain regions. In contrast, variance in cortical thickness was similar for males and females. These findings were supported by multivariate analysis accounting for structural covariance, and present and stable across the lifespan. Additionally, we examined variability among brain regions by sex. We found significant age-by-sex interactions a

SUBMITTER: Forde NJ 

PROVIDER: S-EPMC7566684 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature