Association Between the miR-146a Rs2910164 Polymorphism and Childhood Acute Lymphoblastic Leukemia Susceptibility in an Asian Population.

ABSTRACT: Background: miR-146a has been demonstrated to be involved in normal hematopoiesis and the pathogenesis of many hematological malignancies by inhibiting the expression of its targets. Rs2910164(G>C) may modify the expression of the miR-146a gene, which might influence an individual's predisposition to childhood acute lymphoblastic leukemia (ALL). However, inconsistent findings have been reported on the association between the rs2910164(G>C) polymorphism and the risk of childhood ALL. Methods: A comprehensive meta-analysis was performed to accurately estimate the association between the miR-146a rs2910164 polymorphism and childhood ALL among four different genetic models. Results: This meta-analysis included Asian studies with a total of 1,543 patien

SUBMITTER: Zou D 

PROVIDER: S-EPMC7567015 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature